A Practical Guide to Exocrine Pancreatic Insufficiency (EPI)
An evidence-based guide for veterinary interns on the diagnosis and management of EPI in dogs and cats.
Scroll down to explore Pathophysiology, Diagnosis, Management, and a Knowledge Check.
Pathophysiology & Etiology
Exocrine Pancreatic Insufficiency is a syndrome of maldigestion caused by an insufficient synthesis and secretion of digestive enzymes from the acinar cells of the pancreas.
Clinical Signs & Diagnosis
The clinical signs of EPI are a direct result of maldigestion. A specific blood test is the gold standard for diagnosis.
Treatment & Management
Management is centered on lifelong enzyme replacement, dietary modification, and supplementation of cobalamin (Vitamin B12).
Monitoring & Prognosis
With appropriate management, the prognosis for EPI is generally good.
Knowledge Check
Test your understanding of the key concepts presented in this guide.
This tool is for educational purposes and should not replace clinical judgment. Treatment protocols should always be tailored to the individual patient.